What is Camelyn-Bio?
CAMELYN BIO is a preparation containing biologically active substances, including exogenous peptides isolated from mountain honey. CAMELYN BIO is used to harmonize immune homeostasis in order to effectively and timely counteract cancer and chronic pathology of infectious nature. The obtained polyacrylamide gel electrophoresis, MHP-mountain honey peptides, have a complex protein structure and consist of several molecular regions: the central segment of the CP (central / core peptide) of the molecule stabilizes two peripheral peptide chains: active AP (active peptide) and binding BP (binding peptide). The central peptide provides an opportunity for peripheral conduction of active peptide-peptide interactions: activating or binding other protein molecules. The molecular weight of MHP is on average 65-75 kDa.
CAMELYIN BIO – VALID MARKER OF RADIUM CELLS
It is important to note that infected and atypical cells as per structure are almost identical to healthy cells and, therefore, for T-lymphocytes and macrophages, fulfillment of their main task of recognition of danger becomes very difficult, and sometimes impossible. This phenomenon was called “onco-mimicry” and studied from the 70s of the last century. The ability of the tumors to mimic, interacting with the immune cells through false signals has been known for over 20 years.
Developing by means of the surrounding tissues, cancer cells make maximum to survive and keep their receptors intact, that is, inactive. Exogenous Camelyn-Biopeptides can bind to intact cancer cell receptors and mask it. T-lymphocytes are able to identify dangerous cell and begin work on its destruction, as well as “licensed” macrophages for capturing and evacuating toxic residues.
Exogenous peptides due to effect of tissue accumulation (TAE-tissue accumulation effect) can mask the maximum amount of cancer cells, surround tumor hems and prevent metastases. The use of Camelyn-Bio in patients with cancer pathology makes it possible to stop the progression of the disease and to control the antitumor immune response of the body.
CAMELYN BIO – A POWERFUL INDUCTOR OF INACTIVE T-LYMPHOCYTES
Activation process, or as recently adopted, “recruiting” of lymphocytes is difficult and carries a whole cascade of interactions of extracellular, membrane and intracellular structures. Studies have shown that in order for lymphocyte to react an the infection, its internal receptors should receive protein signals from pathogens: viruses or bacteria. In this process, the causal role plays catelcidine. It activates the pores through which bacterial fragments enter the lymphocyte and activate the NLR (NOD-like receptors).
In conditions of chronic infection and / or in the development of cancer, under conditions of chronic immune deficiency there is a violation of peptide-peptide interactions in the body. Regulatory protein LL-37 often remains inactive, the cell calcification time does not pass the fragments of pathogens and NOD-like receptors of lymphocytes do not receive signals from bacteria and viruses. Many lymphocytes remain inactive, the cascade of immune responses is not triggered in full.
Exogenous peptides MHP, as representatives of one of the most evolutionarily ancient families of proteins, entering the body, come into complex and diverse peptide-peptide interactions with human regulatory proteins. For example, having a similar molecular weight with catelcidine, MHP is able to act as its activator and, therefore, induces inactive T-lymphocytes to effectively counteract pathogens.
CAMELYN BIO – EFFECTIVE ANTITUMOR DETOXICANT
Equally important is the work of the immune system in cases where the patient has to undergo chemotherapy or radiation therapy. For example, when exposed to radiation, the tissue of the tumor is destroyed, saturating the body with toxic fragments. The tissues of the tumor are disintegrating, fragmenting, die. This is the strongest stress for the body, life-threatening intoxication. Protein fragments of destroyed cancer cells need to be recognized and disposed of, with which are called to handle macrophages.
It should be noted that the main problem for purifying the body from the remains of destroyed cells is, above all, their diverse spatial dimensions and molecular mass. It is also important that each fragment has its antigenic structure, making it difficult for macrophages to recognize and utilize.
Camelyn-Bio peptides with the help of peripheral peptide chains bind to residues of destroyed cells, toxic protein fragments and stabilize them. Connected with the MNR protein residues acquire large sizes and their molecular weight due to peptides Camelyn-Bio reaches 30 or more kDa. Increased sizes of the fragments allows the macrophages to find the targetquickly. Stabilized fragments of the molecules are easier to absorb, but most importantly, all Kamelyn-Biopeptide-stabilized fragments have the same signal region, which allows licensed macrophages not only capture them more quickly and efficiently, but also to transmit information on the immune cascade to the largest number of immune cells.
PREVENTION OF REZIDIVES AND METASTASIS
Due to the effect of tissue accumulation, exogenous peptides create additional obstacles to the formation of invasive centers for circulating tumor cells and metastatic embolisms. Moreover, due to its evolutionarily programmed ability to react with other protein structures, the exogenous peptides of Camelyn-Bio add up to tumor cell membranes and thus provoke their more productive interactions with T-lymphocytes, NK cells and macrophages. Macrophages synthesize TNF and are licensed even more macrophages of T-cells to fight tumors, increases the intensity of expression of antitumor interleukin-12. This, in turn, leads to increased immune tumor surveillance, prevents relapse and prevents metastases.
PREVENTION OF MALIGNATION
The role of viruses and toxic substances in malignancy (malignant degeneration) of healthy cells is known. This process is also regulated by peptides. For example, in conditions of chronic damage of liver cells (hepatocytes), the significance of a specific protein of glipikan-3 was determined. With alcoholic liver disease, with toxic and viral hepatitis, the role of this peptide on cell membranes is recognized as a determining factor in the development of the disease. And the higher the activity of glypikan, the greater possibility of malignancy in the liver cells.
Glypican-3 has central and peripheral peptide chains (HS). To start the process of malignancy and further proliferation of cancer cells, glypicin with the help of peripheral proteinaceous HS-chains, should be linked with the HGF protein.
of peripheral proteinaceous HS-chains, should be linked with the HGF protein
Due to tissue accumulation, exogenous MHP peptides, in contact with liver cell membranes, block the HS-chains of glypikan-3 and interfere with their interaction with HGF. As a result, the risk of malignancy of hepatocytes and complication of hepatitis with liver cancer is reduced. And in case of hepatocellular carcinoma diagnosis – the process of disease is stoppes, quality and life expectancy is improved.
URGENTIAL PATHOLOGY: CAMELYN BIO PROVIDES THERAPEUTIC SYNERGY
The effect of tissue accumulation of exogenous peptides is the key to understanding of mechanisms for the harmonization of immune homeostasis in patients with chronic bacterial prostatitis. In urological practice, Camelyn-Bio causes a more pronounced positive dynamics in the growth of the immunoregulatory index, as well as a relatively higher increase in the number of activated T-lymphocytes. This leads to significant better results of the integrated treatment of infectious-inflammatory processes of the prostate.
Camelyn-Bio in the complex management of cervix dysplasia of I, II phase, caused by a mixed chlamydial-papillomavirus infection. Adequate complex therapy, taking into account the role of exogenous peptides, reduces the activity of the human papillomavirus (HPV), its elimination, which reduces the frequency of relapses. Camelyn-Bio provides increased concentration of secretory immunoglobulin A (sIgA) in the mucus of the cervical canal, as well as contributes to the normalization of expression of CD3 and CD4 lymphocytes, stimulates the synthesis of interleukins 1 and 18.
Thus, the effect of tissue accumulation of exogenous regulatory peptides of mountain honey (MHP-mountain honey peptides) leads to the formation of a complex set of sequential and cross-biological reactions that serve the sole purpose of restoring immune homeostasis. MHP compensates the lost reserves of the immune system for effectively counteract malignant tumors and chronic infections.