Effective prevention of breast cancer recurrence: the role of exogenous peptides mhp in restoring immune homeostasis
Abstract The article reveals the current state of the problem of early recurrence and metastasis of breast cancer (BC) and provides basic molecular and cellular mechanisms of how tumor cells avoid the immune surveillance system. The article stresses the importance of the phenomenon of epithelial-mesenchymal transition in the ability of epithelial cells to invade surrounding tissues and metastasize to distant organs, as well as focuses on circulating tumor cells as the main factor of unfavorable prognosis of the disease. We present the results of integrating Сamelyn Bio – product made of exogenous peptides – in the scheme of management of breast cancer. In the group of patients receiving exogenous peptides we observed harmonization of immune homeostasis, manifested by increased immune surveillance of the tumor process involving activated T cells, and increased expression of TNF-α and IL-12. Within 18 months of observation in 95.8% of patients treated with Camelyn Bio we haven’t observed recurrence and metastases, while in the comparison group, this index was 89.6%. These clinical data demonstrate the effectiveness of Camelyn Bio in harmonization of immune homeostasis in patients with breast cancer, which leads to increased immune surveillance of the tumor process and consequently prevents recurrence and metastases. Key words: breast cancer, recurrence, metastases, epithelial-mesenchymal transition, circulating tumor cells, exogenous peptides, Camelyn Bio, immune homeostasis, T-cells, macrophages, interleukin-12, TNF-α, immune surveillance.