A new look at endometriosis: the role of restoring of full immune surveillance over ectopic cells of the endometrium
S.M. Melnikov, O.F. Tatskyy
The article deals with the role of immunological disorders in the occurrence of genital endometriosis recurrences, as well as the results of treatment of this disease.
The objective: the study of the effect of restoring immune homeostasis with the help of exogenous peptides on the effectiveness of the treatment of endometriosis.
Materials and methods. Endometriosis was treated in 68 women of childbearing age. In 48 patients, uterine endometriosis (adenomyosis) was diagnosed, and 20 cases were endometriosis of the vaginal part of the cervix. In order to study the effectiveness of Camelyn Bio in the treatment of endometriosis, patients were divided into two groups.
Results. In the group of patients who were prescribed hormonal monotherapy, 3 months after the end of the course of hormonal treatment, recurrence of endometriosis was observed. They arose due to systemic and local immunological disorders, which probably led to ectopic endometrial cells from immune surveillance. Due to the properties of the exogenous peptides of the Camelyn Bio preparation, reacting with the regulatory peptides of the ectopic cells of the endometrium, there are conditions for a complete immunological surveillance of the endometrium foci. In the group of patients treated with Camelyn Bio, the incidence of relapse was 4 times lower than that of the control group.
Conclusion.Treatment of endometriosis with the combined progestogen and estragon drug is effective and contributes to a sustained regression of the clinical symptoms of the disease. A break in the use of basic hormonal therapy leads to relapses of endometriosis, which is confirmed by the instrumental methods of research. Clinical experience confirms that the restoration of the immune homeostasis of patients with the Camelyn Bio preparation is an important factor in increasing the effectiveness of endometriosis treatment, leads to clinical remission and improves the quality of life.
Key words: endometriosis, ectopic cells of the endometrium, apoptosis, Camelyn Bio, immune homeostasis, relapses, treatment.